Scientific Founders

Paul Chang, PhD

Dr. Chang is an expert in the biology of PARPs and a leader in the field. Prior to joining Ribon, Dr. Chang was the Howard S. and Linda B. Stern Assistant Professor at the Koch Institute for Integrative Cancer Research at MIT where his laboratory focused on PARPs and their role in cancer stress response. While at MIT, Dr. Chang received many awards including the Rita Allen Foundation fellow and Sidney Kimmel Foundation for Cancer Research fellow. Dr. Chang was the organizer and Co-chair (2015) and is the Chair (2017) of the NAD+ Signaling and Metabolism conference sponsored by the Federation of American Societies for Experimental Biology.

Dr. Chang received his PhD in Biology at Stanford University and completed a postdoctoral fellowship at Harvard Medical School with Tim Mitchison. He completed his BS at the University of Wisconsin-Madison.

W. Lee Kraus, PhD

Dr. Kraus is a leader in the PARP field, using integrated approaches to study PARP biology, nuclear signaling pathways, chromatin structure, transcription, and the regulation of gene expression in normal and disease states. He is currently Professor and Director of the Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center in Dallas. Prior to this position, Dr. Kraus was Professor of Molecular Biology and Genetics at Cornell University in Ithaca, New York. He was awarded the Burroughs Welcome Fund Career Award in the Biomedical Sciences, the Ernst Oppenheimer Award for excellence in endocrine research from the Endocrine Society, and numerous other awards. He is also the founding organizer of the Cold Spring Harbor Laboratory PARP meeting.

Dr. Kraus received his PhD from the University of Illinois, Urbana-Champaign, completing his graduate research on steroid hormone receptor-dependent gene regulation in the laboratory of Dr. Benita S. Katzenellenbogen. He completed his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Dr. Jim Kadonaga at the University of California, San Diego.

Tim Mitchison, PhD

Dr. Mitchison is a systems biologist and a pioneer in the study of cell division. He is the Hasib Sabbagh Professor of Systems Biology and Deputy Chair of the Department of Systems Biology at Harvard Medical School, which he helped found along with the Institute of Chemistry and Cell Biology. Prior to HMS, he was Professor at University of California, San Francisco. Dr. Mitchison pioneered the use of high-content phenotypic screening that led to identification of novel inhibitors of the mitotic kinesin Eg5/KSP, an anti-cancer target that has led to several Phase III studies. Mitchison is a former Searle scholar, a fellow of the Royal Society, a member of the National Academy of Sciences, and a member of the American Academy of Arts and Sciences. In addition to these honors, he is also a past president of the American Society for Cell Biology.

Dr. Mitchison earned his Ph.D. in Biochemistry and Biophysics in 1984 from the University of California, San Francisco where he also completed postdoctoral work with Dr. Marc Kirschner.  He received a B.A. in Biochemistry in 1980 from the University of Oxford in England.

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